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CAS 330784-47-9
Langyou
330784-47-9
330784-47-9
Essential Information:
Item: Avanafil
CAS Number: 330784-47-9
Appearance: White Crystalline Powder
Purity level: 99%
Molecular Formula: C23H26ClN7O3
MW: 483.95
Packaging: Available in 1-2 kg Aluminum Foil Bags and 25 kg Drums, supplied directly from the factory.
Sample: Available (Freight charges must be settled)
Monthly Production Capacity: 200 kilograms
Payment Conditions: Full payment via T/T, Western Union, MoneyGram, Bitcoin, Tether, Monero, or bank transfer is required.
Shipping will commence promptly upon receipt of payment.
Please be advised: Customs Assurance
Synonyms include: 4-[[3-Chloro-4-Methoxyphenyl]Methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl) pyrimidine-5-carboxamide; Avanafil, a PDE5 inhibitor; vanafil; (S)-4-((3-Chloro-4-Methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl) pyrimidine-5-carboxamide; Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; avanfil; (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl).
Description:
Avanafil (Zepeed) received approval from the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. This medication is classified as a highly selective type 5 phosphodiesterase (PDE5) inhibitor and is recognized as the most selective PDE5 inhibitor available in the market. The Tmax onset and half-life differ among the various PDE5 inhibitors currently marketed. For instance, sildenafil exhibits a Tmax of 1 hour and a half-life ranging from 3 to 5 hours, while vardenafil has a Tmax of 0.6 hours and a half-life between 4 and 6 hours. Tadalafil is noted for having the longest half-life among these medications, measuring at 17 hours. In contrast, avanafil demonstrates a rapid onset of action, achieving Tmax in 0.6 hours, with a half-life of 1.2 hours. The synthesis of avanafil (TA-1790) is detailed within patent literature. The primary route of elimination for avanafil occurs through bile and feces, and it has also been observed to undergo reabsorption via enterohepatic recirculation.
Avanafil was initially discovered at Tanabe Seiyaku, which is now known as Mitsubishi Tanabe. The drug has since been developed and introduced to the market by JW Pharmaceutical, formerly Choongwae Pharma, and VIVUS. This oral PDE5 inhibitor is utilized for the treatment of erectile dysfunction (ED). While several PDE5 inhibitors, such as sildenafil, vardenafil, and tadalafil, are currently available for managing ED, a significant number of patients still struggle to attain the desired outcomes and encounter unwanted side effects from these existing treatments. Consequently, there is a demand for second-generation PDE5 inhibitors that offer enhanced selectivity for PDE5, reduced systemic half-lives, and improved tolerability. Avanafil was designed to fulfill these requirements, demonstrating favorable oral bioavailability and PDE5 selectivity in both preclinical and clinical research. Furthermore, avanafil is characterized by a rapid onset of action (35 minutes) and a brief half-life (1.5 hours).
Avanafil undergoes metabolism primarily in the liver through the cytochrome P450 isoenzyme CYP3A4, with a lesser contribution from the CYP2C isoform. The process yields two significant metabolites, one of which retains activity. The excretion of avanafil occurs predominantly through metabolites in the feces, accounting for approximately 63%, while around 21% is eliminated via urine.
Advantage:
Hubei Langyou International Trading Co., Ltd is a distinguished manufacturer in the pharmaceutical sector. Our commitment is to provide high-quality products at competitive prices, ensuring prompt delivery with a guarantee of 100% customs clearance. Upholding our philosophy of continuously striving to deliver exceptional service is paramount to us. We offer flexible and untraceable payment options. As a prominent manufacturer, our products have been exported to numerous countries, including Germany, Norway, Poland, Finland, Spain, the UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many others.
Each batch of our products must undergo testing by our Quality Control (QC) department prior to being permitted for sale.
2. Delivery: Our inventory is readily available, allowing for prompt delivery on the same day that payment is received. Delivery will occur within 24 hours following payment, with a lead time of either 4 or 7 days.
3. Packaging: Guaranteed Discreet and Professional Packaging. To ensure your safety and facilitate successful delivery, all items will be packaged in a manner that maintains discretion, preventing any potential suspicions. No product-related names will be displayed on the parcels, contributing to a high rate of successful deliveries.
4. Warm After-Sale Service: Should you have any inquiries, please do not hesitate to reach out to us at your convenience; we will respond promptly at the earliest opportunity.
Top-Selling Products:
The following compounds are identified by their respective CAS numbers: CAS 30123-17-2 Tianeptine Sodium Salt, CAS 66981-73-5 Tianeptine, CAS 90212-80-9 CRL-40,941, CAS 110-63-4 1,4-Butanediol (BDO), CAS 385769-84-6 Amino Tadalafil, CAS 171596-29-5 Tadalafil, CAS 330784-47-9 Avanafil, CAS 224785-90-4 Vardenafil, CAS 68497-62-1 Pramiracetam, CAS 110958-19-5 Fasoracetam, CAS 72432-10-1 Aniracetam, CAS 77191-36-7 Nefiracetam, CAS 135463-81-9 Coluracetam, CAS 62613-82-5 Oxiracetam, CAS 77472-71-0 Phenylpiracetam Hydrazide, CAS 314728-85-3 Sunifiram, CAS 56786-63-1 5-alpha-Hydroxy-Laxogenin, CAS 7791-07-3 Sodium Perchlorate Monohydrate, CAS 1890208-58-8 Compound 7P, CAS 138112-76-2 Agomelatine, CAS 10102-18-8 Sodium Selenite, CAS 862189-95-5 Linezolid, CAS 38183-03-8 7,8-Dihydroxyflavone, CAS 1143-70-0 Urolithin A, CAS 55237-19-1 4F-Phenibut, CAS 334-50-9 Spermidine trihydrochloride, and CAS 124-20-9 Spermidine.
CAS 67881-98-5 refers to 2-methacryloyloxyethyl phosphorylcholine (MPC), while CAS 784-38-3 designates 2-Amino-5-chloro-2'-fluorobenzophenone.
CAS 1224690-84-9 refers to Tianeptine hemisulfate monohydrate (THM).
Contact Information:
Email Address: niyoe@protonchem.cn
WhatsApp/Telegram contact number: +86-17720330692.
Threema Identification: DA4UTK6D
Essential Information:
Item: Avanafil
CAS Number: 330784-47-9
Appearance: White Crystalline Powder
Purity level: 99%
Molecular Formula: C23H26ClN7O3
MW: 483.95
Packaging: Available in 1-2 kg Aluminum Foil Bags and 25 kg Drums, supplied directly from the factory.
Sample: Available (Freight charges must be settled)
Monthly Production Capacity: 200 kilograms
Payment Conditions: Full payment via T/T, Western Union, MoneyGram, Bitcoin, Tether, Monero, or bank transfer is required.
Shipping will commence promptly upon receipt of payment.
Please be advised: Customs Assurance
Synonyms include: 4-[[3-Chloro-4-Methoxyphenyl]Methyl]amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl) pyrimidine-5-carboxamide; Avanafil, a PDE5 inhibitor; vanafil; (S)-4-((3-Chloro-4-Methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl) pyrimidine-5-carboxamide; Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; avanfil; (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl).
Description:
Avanafil (Zepeed) received approval from the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. This medication is classified as a highly selective type 5 phosphodiesterase (PDE5) inhibitor and is recognized as the most selective PDE5 inhibitor available in the market. The Tmax onset and half-life differ among the various PDE5 inhibitors currently marketed. For instance, sildenafil exhibits a Tmax of 1 hour and a half-life ranging from 3 to 5 hours, while vardenafil has a Tmax of 0.6 hours and a half-life between 4 and 6 hours. Tadalafil is noted for having the longest half-life among these medications, measuring at 17 hours. In contrast, avanafil demonstrates a rapid onset of action, achieving Tmax in 0.6 hours, with a half-life of 1.2 hours. The synthesis of avanafil (TA-1790) is detailed within patent literature. The primary route of elimination for avanafil occurs through bile and feces, and it has also been observed to undergo reabsorption via enterohepatic recirculation.
Avanafil was initially discovered at Tanabe Seiyaku, which is now known as Mitsubishi Tanabe. The drug has since been developed and introduced to the market by JW Pharmaceutical, formerly Choongwae Pharma, and VIVUS. This oral PDE5 inhibitor is utilized for the treatment of erectile dysfunction (ED). While several PDE5 inhibitors, such as sildenafil, vardenafil, and tadalafil, are currently available for managing ED, a significant number of patients still struggle to attain the desired outcomes and encounter unwanted side effects from these existing treatments. Consequently, there is a demand for second-generation PDE5 inhibitors that offer enhanced selectivity for PDE5, reduced systemic half-lives, and improved tolerability. Avanafil was designed to fulfill these requirements, demonstrating favorable oral bioavailability and PDE5 selectivity in both preclinical and clinical research. Furthermore, avanafil is characterized by a rapid onset of action (35 minutes) and a brief half-life (1.5 hours).
Avanafil undergoes metabolism primarily in the liver through the cytochrome P450 isoenzyme CYP3A4, with a lesser contribution from the CYP2C isoform. The process yields two significant metabolites, one of which retains activity. The excretion of avanafil occurs predominantly through metabolites in the feces, accounting for approximately 63%, while around 21% is eliminated via urine.
Advantage:
Hubei Langyou International Trading Co., Ltd is a distinguished manufacturer in the pharmaceutical sector. Our commitment is to provide high-quality products at competitive prices, ensuring prompt delivery with a guarantee of 100% customs clearance. Upholding our philosophy of continuously striving to deliver exceptional service is paramount to us. We offer flexible and untraceable payment options. As a prominent manufacturer, our products have been exported to numerous countries, including Germany, Norway, Poland, Finland, Spain, the UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many others.
Each batch of our products must undergo testing by our Quality Control (QC) department prior to being permitted for sale.
2. Delivery: Our inventory is readily available, allowing for prompt delivery on the same day that payment is received. Delivery will occur within 24 hours following payment, with a lead time of either 4 or 7 days.
3. Packaging: Guaranteed Discreet and Professional Packaging. To ensure your safety and facilitate successful delivery, all items will be packaged in a manner that maintains discretion, preventing any potential suspicions. No product-related names will be displayed on the parcels, contributing to a high rate of successful deliveries.
4. Warm After-Sale Service: Should you have any inquiries, please do not hesitate to reach out to us at your convenience; we will respond promptly at the earliest opportunity.
Top-Selling Products:
The following compounds are identified by their respective CAS numbers: CAS 30123-17-2 Tianeptine Sodium Salt, CAS 66981-73-5 Tianeptine, CAS 90212-80-9 CRL-40,941, CAS 110-63-4 1,4-Butanediol (BDO), CAS 385769-84-6 Amino Tadalafil, CAS 171596-29-5 Tadalafil, CAS 330784-47-9 Avanafil, CAS 224785-90-4 Vardenafil, CAS 68497-62-1 Pramiracetam, CAS 110958-19-5 Fasoracetam, CAS 72432-10-1 Aniracetam, CAS 77191-36-7 Nefiracetam, CAS 135463-81-9 Coluracetam, CAS 62613-82-5 Oxiracetam, CAS 77472-71-0 Phenylpiracetam Hydrazide, CAS 314728-85-3 Sunifiram, CAS 56786-63-1 5-alpha-Hydroxy-Laxogenin, CAS 7791-07-3 Sodium Perchlorate Monohydrate, CAS 1890208-58-8 Compound 7P, CAS 138112-76-2 Agomelatine, CAS 10102-18-8 Sodium Selenite, CAS 862189-95-5 Linezolid, CAS 38183-03-8 7,8-Dihydroxyflavone, CAS 1143-70-0 Urolithin A, CAS 55237-19-1 4F-Phenibut, CAS 334-50-9 Spermidine trihydrochloride, and CAS 124-20-9 Spermidine.
CAS 67881-98-5 refers to 2-methacryloyloxyethyl phosphorylcholine (MPC), while CAS 784-38-3 designates 2-Amino-5-chloro-2'-fluorobenzophenone.
CAS 1224690-84-9 refers to Tianeptine hemisulfate monohydrate (THM).
Contact Information:
Email Address: niyoe@protonchem.cn
WhatsApp/Telegram contact number: +86-17720330692.
Threema Identification: DA4UTK6D
