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High Purity Avanafil Powder CAS 330784-47-9 in Stock Threema: DA4UTK6D
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High Purity Avanafil Powder CAS 330784-47-9 in Stock Threema: DA4UTK6D

Availability:
Quantity:
  • CAS 330784-47-9

  • Langyou

  • 330784-47-9

  • 330784-47-9

Basic Info:

Product: Avanafil

CAS: 330784-47-9

Form: White Crystalline Powder

Purity: 99%

MF: C23H26ClN7O3

MW: 483.95

Package: 1-2kg/Aluminum Foil Bag, 25kg/Drum Factory supply

Sample: Available (Freight need to be paid)

Production Capacity: 200kg/Month

Payment Terms: 100% T/T, Western Union, Money Gram, Bitcoin, Tether, Monero, Bank Transfer

Delivery Time: Ship out immediately once receiving Payment

Note: Guarantee Customs


Synonyms: 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;AvanafilPDE5inhibitor;vanafil;(S)-4-((3-Chloro-4-Methoxybenzyl)aMChemicalbookino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl.


Description:

Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.


Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).


Avanafil is metabolised in the liver mainly by the cytochrome P450 isoenzyme CYP3A4 and to a minor extent by the CYP2C isoform. Two major metabolites are produced, one of which is active. Avanafil is excreted as metabolites mainly in the faeces (approximately 63%) in the urine (approximately 21%).


Advantage:

Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% CUSTOMS PASS GUARANTEED. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.


1. Quality: Every batch of our products has to be tested by our QC(quality control) before they are allowed to sell.


2. Delivery: Stock is available, so we can deliver quickly on the very day when receiving the payment. Within 24 hours after receiving the payment and Lead time is 4 or 7 days.


3. Package: Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery, all products will be packed in a discreet way to prevent any suspicions, no products-related name will appear on the parcels and have high successful delivery rate

4. Warm After-Sale Service: Any questions, feel free to contact us at any time, we will make a prompt response as soon as possible.


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Contact Info:

Email: niyoe@protonchem.cn

WhatsApp/Telegram: 86-17720330692

Signal: 86-19318001889

Threema ID: DA4UTK6D














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Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed.

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Tel: +86-17720330692

E-mail:niyoe@protonchem.cn

Threema ID: DA4UTK6D

Signal: 86-19318001889

WhatsApp: +86-17720330692  

Telegram: +86-17720330692

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