About Pregabalin cas 148553-50-8
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About Pregabalin cas 148553-50-8

Views: 0     Author: Site Editor     Publish Time: 2023-08-11      Origin: Site


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Pregabalin is a drug primarily used to treat nerve pain, epilepsy and anxiety disorders. It is sold under the brand name Lyrica and was first approved by the US Food and Drug Administration (FDA) in 2004. Since then, pregabalin has become a widely used drug for the treatment of a wide range of conditions. This article will look at the pharmacology, clinical uses, side effects and potential for abuse of pregabalin.


Pregabalin belongs to a class of drugs known as anticonvulsants. It works by binding to a specific type of receptor in the brain called the alpha-2-delta subunit of voltage-gated calcium channels. This binding reduces the release of several neurotransmitters, including glutamate, substance P and norepinephrine, resulting in reduced neuronal excitability and pain perception.

Pregabalin is rapidly absorbed after oral administration, with peak plasma concentrations occurring within one to two hours. The drug is excreted mainly in the urine and its elimination half-life is approximately six hours. Pregabalin is not extensively metabolised in the liver and does not interact with cytochrome P450 enzymes, which are responsible for the metabolism of many other drugs.

Clinical uses

Pregabalin is primarily used for the treatment of nerve pain, including diabetic neuropathy, postherpetic neuralgia and pain due to spinal cord injury. It has also been used as an adjunctive treatment for partial seizures in adults with epilepsy. In addition, pregabalin has been shown to be effective in the treatment of generalised anxiety disorder (GAD) and social anxiety disorder (SAD).

Neuropathic pain

Several randomised controlled trials have demonstrated the effectiveness of pregabalin in the treatment of neuropathic pain. In a study of patients with painful diabetic neuropathy, pregabalin was shown to be more effective than placebo in reducing pain scores and improving sleep quality

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